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詳細解析Cerilliant他克莫司T-049的藥理作用
發布時間： 2020-04-21 點擊次數： 1036次Cerilliant他克莫司T-049是一種非常好的免疫抑制劑，顧名思義，免疫抑制，就是能夠抑制免疫系統里的T淋巴細胞繼續攻擊黑色素，從而達到控制擴散的目的。所以，用他克莫司以后，白斑不在擴大，就是有效，白斑恢復，則為顯效；并不是說，沒有恢復，就是無效的。Cerilliant他克莫司T-049藥性較強，一般用在臉上，都會有灼熱感，這是正常現象。Cerilliant他克莫司T-049的藥理作用：在分子水平，他克莫司的作用顯然是利用與細胞性蛋白質（FKBP12）相結合，而在細胞內蓄積產生效用。FKBP12-他克莫司復合物會專一性地結合以及抑制calcinurin，其會抑制T細胞中所產生鈣離子依賴型訊息傳導路徑作用，因此防止不連續性淋巴因子基因的轉錄。本藥是具有高度免疫抑制的藥物，其活性在體外及體內實驗中都已被證實。本藥抑制形成主要移植排斥作用之細胞毒性淋巴球的生成。本藥抑制T細胞的活化作用以及T輔助細胞依賴B細胞的增生作用。也會抑制如白介素-2、白介素-3及γ-干擾素等淋巴因子的生成與白介素-2受體的表達。在分子水平，本藥的效應似乎是由結合到細胞性蛋白質（FKBP）所產生，此蛋白質也會造成該化合物累積在細胞間。在體內試驗中發現，本藥顯示出對肝臟及腎臟移植有效。- 下一篇：您知道Chemgenes寡核苷酸時如何被合成的嗎？
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